Fig. 6.

Dependence of viral transfer on integrity of endocytic transport. a, b Distribution of myosin II with HIV-1 Env and Gag, in MDM untreated or exposed to CD, Noc or BBST post-formation of BC (scale bar, 10 μm). c–e Disruption of endosome/viral motility by CD, Noc or BBST. Progressive average movement was determined using the mean velocity (μm•s⁻¹), path length (μm), and displacement from the origin for all analyzed particles (error bars, ± S.E.M., n = 70 particles/group, N = 3 independent experiments) at each time point for 120 s