Fig. 3.
Collagen V localizes to fibrotic areas and large vessels. The immunohistochemical staining pattern of collagens IV (A) and V (B) are shown. Collagen IV, a basement membrane protein, was most abundant in blood vessels (arrowheads) and surrounding adipocytes (arrow) and was seldom found in fibrotic areas (asterisk) within the adipose tissue section. In contrast, collagen V was very abundant in fibrotic areas (asterisk) and surrounding blood vessels (arrowheads). Magnification, ×200; bar, 125 μm. C, Quantification of collagen V staining in lean and obese (BMI > 27 kg/m2) subjects. D, Relationship between collagen V mRNA abundance and SI. *, P < 0.05.