Table 3.
Change in physical function measures in relation to baseline sex steroid and SHBG quartiles in men losing weight (≥2.0 kg body weight loss)
| Quartiles |
P valuea | ||||
|---|---|---|---|---|---|
| 1 (lowest) | 2 | 3 | 4 (highest) | ||
| Total T quartiles | |||||
| Range (ng/dl)b | 5.5–303.0 | 304.0–394.0 | 395.0–495.0 | 496.0–1340.0 | |
| n | 121 | 102 | 104 | 99 | |
| Absolute change in grip strength (kg) | −5.1 (−6.7, −3.4) | −3.9 (−5.6, −2.1) | −3.9 (−5.7, −2.0) | −3.4 (−5.4, −1.5) | 0.11 |
| Absolute change in leg power (watts) | −57.9 (−76.4, −39.4) | 46.3 (−660, −26.5) | −41.4 (−61.8, −20.9) | −49.6 (−70.7, −28.5) | 0.36 |
| Absolute change in time to complete five chair stands (sec) | 4.6 (3.2, 6.0) | 2.9 (1.4, 4.4) | 3.1 (1.5, 4.6) | 2.5 (0.9, 4.1) | 0.02 |
| Absolute change in 6-m normal walk pace (m/sec) | −0.17 (−0.23, −0.11) | −0.12 (−0.19, −0.06) | −0.11 (−0.17, −0.04) | −0.12 (−0.19, −0.05) | 0.17 |
| Absolute change in 20-cm narrow walk (m/sec) | −0.35 (−0.46, −0.25) | −0.29 (−0.40, −0.17) | −0.32 (−0.43, −0.20) | −0.25 (−0.37, −0.12) | 0.10 |
| Total E quartiles | |||||
| Range (pg/dl)b | 1.3–17.7 | 17.8–21.9 | 22.0–27.0 | 27.1–97.6 | |
| n | 97 | 111 | 109 | 109 | |
| Absolute change in grip strength (kg) | −4.2 (−6.0, −2.3) | −4.8 (−6.5, −3.0) | −4.0 (−5.8, −2.2) | −3.8 (−5.7, −1.9) | 0.49 |
| Absolute change in leg power (watts) | −51.3 (−71.8, −30.7) | −52.3 (−71.4, −33.2) | −48.9 (−68.4, −29.4) | −48.6 (−69.6, −27.7) | 0.69 |
| Absolute change in time to complete five chair stands (sec) | 4.3 (2.8, 5.9) | 3.6 (2.1, 5.0) | 2.8 (1.3, 4.3) | 3.4 (1.8, 4.9) | 0.20 |
| Absolute change in 6-m normal walk pace (m/sec) | −0.19 (−0.26, −0.12) | −0.11 (−0.17, −0.05) | −0.11 (−0.17, −0.04) | −0.16 (−0.23, −0.09) | 0.61 |
| Absolute change in 20-cm narrow walk (m/sec) | −0.33 (−0.45, −0.21) | −0.34 (−0.45, −0.23) | −0.28 (−0.39, −0.16) | −0.30 (−0.42, −0.18) | 0.53 |
| Baseline SHBG quartiles | |||||
| Range (nmol/liter)b | 13.5–34.2 | 34.3–44.8 | 44.9–57.3 | 57.4–179.0 | |
| n | 107 | 109 | 109 | 101 | |
| Absolute change in grip strength (kg) | −5.5 (−7.2, −3.8) | −4.0 (−5.7, −2.2) | −3.2 (−5.0, −1.3) | −3.5 (−5.4, −1.6) | 0.04 |
| Absolute change in leg power (watts) | −55.0 (−74.2, −35.8) | −52.5 (−71.6, −33.3) | −42.7 (−62.9, −22.5) | −46.4 (−67.7, −25.1) | 0.25 |
| Absolute change in time to complete 5 chair stands (sec) | 4.4 (2.9, 5.8) | 3.5 (2.0, 4.9) | 2.7 (1.2, 4.2) | 2.8 (1.2, 4.5) | 0.06 |
| Absolute change in 6-m normal walk pace (m/sec) | −0.17 (−0.23, −0.11) | −0.12 (−0.19, −0.06) | −0.11 (−0.17, −0.04) | −0.13 (−0.20, −0.06) | 0.31 |
| Absolute change in 20 cm narrow walk (m/sec) | −0.32 (−0.43, −0.21) | −0.36 (−0.47, −0.25) | −0.29 (−0.41, −0.18) | −0.23 (−0.35, −0.11) | 0.07 |
Data are expressed as adjusted mean (95% CI). Means are fully adjusted.
a
P value for model adjusted for clinic site, age group, race, serum selection method, self-reported history of diabetes, self-rated health, and physical summary scale.
b
To convert metric units (ng/dl) to SI (nmol/liter), multiply the concentrations of testosterone by 0.0347 and multiply the concentrations of estradiol by 3.671.