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. 2011 Oct 26;96(12):3687–3694. doi: 10.1210/jc.2011-2149

Fig. 1.

Fig. 1.

Baseline ipsilateral prolactin IPS/P ratios (left panel) and normalized ACTH/prolactin IPS/P ratios (right panel) in 29 patients with ACTH-dependent Cushing's syndrome (25 with a surgically proven diagnosis and four with occult Cushing's syndrome). Patients were divided into true negatives (TN: pathology and IPSS results consistent with EAS, n = 7), true positives (TP: pathology and IPSS results consistent with CD, n = 16), false negatives (FN: negative IPSS results in a patient with surgically proven CD, n = 1), false positive (FP: positive IPSS results in a patient with surgically proven EAS, n = 1), and occult (U: biochemical testing consistent with EAS, but a source could not be localized). Normalized ACTH/prolactin IPS/P ratios in five cases were higher than 12 and are not shown in the above figure. All patients with surgically proven Cushing's disease had a normalized ACTH IPS/P ratio of 1.3 or higher (dotted line). Patients with surgically proven EAS (except for the false-positive case) had a normalized ACTH/prolactin IPS/P ratio of 0.7 or lower (dashed line). CD, Cushing's disease.