Table 3.
IPSS ACTH (pg/ml) and prolactin (ng/ml) data in 29 patients with ACTH-dependent Cushing's syndrome with baseline prolactin IPS/P ratios and normalized ACTH/prolactin IPS/P ratios shown for both inferior petrosal sinuses
| Type | IPSS result | Peak ACTH IPS/P | Contralateral Peak ACTH IPS/P | Ipsilateral BL PRL IPS/P | Contralateral BL PRL IPS/P | Ipsilateral normalized peak ACTH/BL PRL IPS/P | Contralateral normalized peak ACTH/BL PRL IPS/P | Concordant normalized ratios |
|---|---|---|---|---|---|---|---|---|
| EAS | TN | 1.2 | 1.1 | 1.8 | 3 | 0.7 | 0.4 | Yes |
| EAS | TN | 1.5 | 1.4 | 3.1 | 2.4 | 0.5 | 0.6 | Yes |
| EAS | TN | 1.1 | 1.1 | 4 | 4.1 | 0.3 | 0.3 | Yes |
| EAS | TN | 1.4 | 1.3 | 5.4 | 2.1 | 0.3 | 0.6 | Yes |
| EAS | TN | 1.1 | 1.1 | 4.8 | 1.3 | 0.2 | 0.8 | No |
| EAS | TN | 1.2 | 1.1 | 4.7 | 2.4 | 0.3 | 0.5 | Yes |
| EASa | TN | 1.4 | 1.0 | 3.9 | 1.0 | 0.4 | 1.0 | No |
| EAS | FP | 9.5 | 5.7 | 1.7 | 1.5 | 5.6 | 3.8 | Yes |
| CD | TP | 20.4 | 1.0 | 4.7 | 1 | 4.3 | 1 | Yes |
| CD | TP | 113.4 | 100.2 | 10.9 | 8 | 10.4 | 12.5 | Yes |
| CD | TP | 53.6 | 11.9 | 5 | 4.1 | 10.8 | 2.9 | Yes |
| CDa | TP | 131.7 | 15.6 | 6.2 | 2.2 | 21.4 | 7.1 | Yes |
| CD | TP | 20 | 17.7 | 2 | 2.4 | 10.1 | 7.4 | Yes |
| CDa | TP | 49.2 | 6.7 | 5.7 | 3.8 | 8.6 | 1.8 | Yes |
| CD | TP | 87.5 | 1.6 | 2.1 | 1.4 | 40.9 | 1.1 | Yes |
| CD | TP | 9.7 | 1.0 | 0.8 | 0.8 | 11.6 | 1.3 | Yes |
| CD | TP | 18.5 | 12.1 | 3.6 | 2.9 | 5.1 | 4.2 | Yes |
| CDa | TP | 167.3 | 6.2 | 4.7 | 3.9 | 35.5 | 1.6 | Yes |
| CDa | TP | 37.7 | 3.5 | 2.2 | 1.2 | 16.8 | 2.9 | Yes |
| CDa | TP | 36.3 | 26.8 | 10.9 | 2.7 | 3.3 | 9.9 | Yes |
| CD | TP | 9.2 | 1.5 | 1.1 | 1.0 | 8.4 | 1.5 | Yes |
| CDa | TP | 11.3 | 0.9 | 2.9 | 1.0 | 3.9 | 0.9 | Yes |
| CD | TP | 40.9 | 2.8 | 3.4 | 1.9 | 11.9 | 1.5 | Yes |
| CD | TP | 78.2 | 1.2 | 3.1 | 1.7 | 24.9 | 0.7 | No |
| CDa | FN | 1.3 | 1.2 | 1 | 1.6 | 1.3 | 0.8 | No |
| Occ 1 | 1.3 | 1.2 | 13.2 | 1.1 | 0.1 | 1.1 | No | |
| Occ 2a | 2.3 | 1.1 | 4.2 | 0.8 | 0.6 | 1.4 | No | |
| Occ 3a | 1.3 | 1.2 | 1.2 | 1.2 | 1.1 | 1 | Yes | |
| Occ 4a | 1.4 | 1.2 | 1.6 | 1.1 | 0.9 | 1.1 | Yes |
The ipsilateral calculations represent the side with the highest ACTH IPS/P value; contralateral results reflect the opposite side. Discordant results for normalized ACTH/prolactin IPS/P ratio were seen in six of the 29 patients and are shown in bold. BL, Baseline; CD, Cushing's disease; FN, false negative; FP, false positive; Occ, occult; PRL, prolactin; TP, true positive; TN, true negative.
a
Patients with abnormal venous anatomy.