Table 3.

Multivariable linear-regression models for the expression of each target^a

Target and parameter	FC	P value
S100A7
Gender (female)	0.68	0.003
Age (yr)	1.04	0.11
Follicular trachoma (F2/F3)	2.39	<0.0001
Bacterial infection	1.37	0.03
IL1B
Gender (female)
Age (yr)	0.96	0.13
Follicular trachoma (F2/F3)
Bacterial infection	1.22	0.16
IL17A
Gender (female)	1.15	0.18
Age (yr)	0.92	<0.0001
Follicular Trachoma (F2/F3)	2.53	<0.0001
Bacterial infection	1.83	<0.0001
IL23A
Gender (female)	0.86	0.04
Age (yr)
Follicular trachoma (F2/F3)	1.17	0.17
Bacterial infection	1.22	0.02
CXCL5
Gender (female)
Age (yr)	0.94	0.06
Follicular trachoma (F2/F3)	3.40	<0.0001
Bacterial infection	1.64	0.008
CCL18
Gender (female)
Age (yr)	0.93	0.0004
Follicular trachoma (F2/F3)	2.55	<0.0001
Bacterial infection	2.05	<0.0001
NLRP3
Gender (female)
Age (yr)	0.98	0.02
Follicular trachoma (F2/F3)
Bacterial infection	1.19	0.004
KLRD1
Gender (female)
Age (yr)	0.91	<0.0001
Follicular trachoma (F2/F3)
Bacterial infection	1.42	<0.0001
TLR2
Gender (female)	0.95	0.19
Age (yr)	0.99	0.15
Follicular trachoma (F2/F3)	1.16	0.02
Bacterial infection	1.11	0.02
CTGF
Gender (female)
Age (yr)	0.97	0.03
Follicular trachoma (F2/F3)	2.04	<0.0001
Bacterial infection	1.20	0.04
MMP9
Gender (female)
Age (yr)
Follicular trachoma (F2/F3)	0.82	0.04
Bacterial infection

^aTerms were retained in the model if their P value was <0.2, by likelihood ratio testing. FC, fold changes, which were derived from the models. The specific comparisons within these terms of the model were female versus male, age as a continuous variable in years, follicular trachoma (F2 or F3) versus no follicular trachoma (F0 or F1), and bacterial infection versus no bacterial infection. Using the Bonferroni correction for multiple comparisons, the critical significance threshold level is a P value of <0.0016.