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. 2011 Dec;79(12):4791–4801. doi: 10.1128/IAI.05808-11

Fig. 8.

Fig. 8.

Murine B-1a cells from TLR2-knockout (TLR2−/−) BALB/c mice did not respond to either H. pylori (SS-1 or NCTC 11637)-coated plates (A) or purified H. pylori (SS-1 or NCTC 11637) urease (B). (A) Two × 105 purified murine B-1a cells from either normal wild-type BALB/c mice (WT) or TLR2−/− mice were cultured in plates precoated with H. pylori (SS-1 or NCTC 11637) (filled columns) or PBS (open columns) for 7 days, and autoantibody secretion in the culture supernatant was measured. Results are expressed as means ± SDs (n = 5). (B) Purified murine B-1a cells (2 × 105) from either normal wild-type BALB/c mice or TLR2−/− BALB/c mice were cultured with 10 μg/ml purified H. pylori urease (filled columns) or PBS (open columns) for 7 days, and autoantibody secretion in the culture supernatant was measured. Results are expressed as means ± SDs (n = 5). Statistical significance was determined by the Student t test, and the values are given in each graph.