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Rapid induction of proinflammatory cytokines in the absence of Hip1. C57BL/6 BMM were infected with the wt or hip1 mutant strain at an MOI of 10. Supernatants were collected at 5, 8, 24, and 72 h postinfection and were assayed for IL-1β, IL-6, and TNF-α by ELISA. Values are presented as means plus SD, and the data are representative of 3 independent experiments. *, P < 0.05; **, P < 0.01; ***, P < 0.001.
