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. 2011 Dec;79(12):5027–5038. doi: 10.1128/IAI.05524-11

Fig. 5.

Fig. 5.

Serum IgG responses in orally immunized and control mice. Total serum IgG specific for rPspA (A), IgA specific for rPspA (B), and IgG specific for SOMP (C) were measured by ELISA. The data represent reciprocal anti-IgG antibody levels in pooled sera from mice orally immunized with attenuated Salmonella carrying either pYA4088 (pspA) or pYA3493 (control) at 4 and 8 weeks after immunization (4w and 8w, respectively). The error bars represent variations between triplicate wells. The mice were boosted at week 5. ***, P < 0.001; **, P < 0.01; *, P < 0.05 compared with χ9241(pYA4088). †††, P < 0.001; ††, P < 0.01; †, P < 0.05 compared with χ9278(pYA4088). No immune responses to PspA were detected in mice immunized with χ9241 containing the control plasmid (reciprocal titer of <1:50 for IgG and <1:25 for IgA).