Table 1.
Medullary GABAA Receptor Binding Density in SIDS cases and Controls in Stage 1
| SIDS Cases (n = 6) (fmol/mg tissue) Mean (SE) |
Control Cases (n = 5) (fmol/mg tissue) Mean (SE) |
p value | % Decrease | |
|---|---|---|---|---|
| Medullary 5-HT source nuclei | ||||
| Raphé obscurus | 29.1 (9.8) | 80.7 (10.8) | 0.001 | 63% |
| Paragigantocellularis lateralis | 31.8 (6.6) | 62.4 (7.3) | 0.020 | 49% |
| Gigantocellularis | 41.1 (8.6) | 78.6 (9.5) | 0.020 | 48% |
| Intermediate reticular zone | 43.7 (7.6) | 71.8 (8.4) | 0.040 | 39% |
| Arcuate nucleus | 35.0 (9.1) | 50.4 (10.1) | 0.300 | 31% |
| Medullary 5-HT projection nuclei | ||||
| Medial accessory olive | 39.9 (6.4) | 42.1 (7.0) | 0.830 | 5% |
| Nucleus of the solitary tract | 43.4 (5.5) | 80.8 (6.1) | 0.002 | 46% |
| Hypoglossal nucleus | 51.1 (8.3) | 77.6 (9.2) | 0.070 | 34% |
| Dorsal accessory olive | 29.8 (8.8) | 76.6 (9.7) | 0.008 | 61% |
| Principal inferior olive | 36.9 (6.4) | 49.9 (6.8) | 0.200 | 26% |
Abbreviations: SIDS, sudden infant death syndrome; 5-HT, serotonergic system.