Table 6.
GABAA Receptor Binding and GABAAα3 Subunit Expression Levels in SIDS Cases Found Dead in the Prone vs. Supine Sleep Position
| Prone | Supine | t-test | |||||
|---|---|---|---|---|---|---|---|
| N | Mean | SE | N | Mean | SE | p value | |
| ARC | 13 | 26.1 | 3.64 | 5 | 29.2 | 9.38 | 0.71 |
| NTS | 12 | 41.1 | 4.04 | 5 | 36.6 | 5.54 | 0.54 |
| HG | 13 | 43.4 | 4.66 | 5 | 44.9 | 11.91 | 0.89 |
| PIO | 13 | 28.5 | 3.49 | 5 | 29.3 | 4.06 | 0.90 |
| MAO | 13 | 35.9 | 3.8 | 5 | 42.6 | 6.49 | 0.38 |
| GC | 11 | 36.2 | 4.01 | 5 | 29.3 | 3.23 | 0.30 |
| PGCL | 11 | 28.5 | 2.94 | 5 | 24.9 | 2.39 | 0.45 |
| IRZ | 11 | 33.0 | 4.39 | 5 | 29.7 | 1.96 | 0.50 |
| DAO | 11 | 35.7 | 3.57 | 5 | 29.9 | 1.64 | 0.16 |
| ROB | 11 | 28.6 | 4.48 | 5 | 27.9 | 4.52 | 0.93 |
| Western blot | 6 | 59.6 | 13.72 | 6 | 79.0 | 32.06 | 0.59 |
GABAA receptor binding is expressed as fmol/mg of tissue; GABAAα3 subunit expression levels by Western blot are percent of standard.
Abbreviations: SE; standard error; ARC, arcuate nucleus; NTS, nucleus of the solitary tract; HG, hypoglossal nucleus; PIO, principal inferior olive; MAO, medial accessory olive; GC, gigantocellularis; PGCL, paragigantocellularis lateralis; IRZ, intermediate reticular zone; DAO, dorsal accessory olive; ROB, raphé obscurus.