Table 7.
Medullary GABAA Receptor Binding Density in SIDS Cases and Controls in Stage 3.
| Age-Adjusted | Mean (SE) | ||||||
|---|---|---|---|---|---|---|---|
| SIDS Cases (n=34) |
Acute Controls (n=7) |
Chronic Controls (n=6) |
3 way p value |
Combined Controls (n=13) |
% Decreased |
* p value | |
| Medullary 5-HT source nuclei | |||||||
| Raphé obscurus | 26.5 (3.4) | 55.9 (7.0) | 63.9 (8.5) | <0.001 | 59.2 (5.4) | 55% | <0.001 |
| Paragigantocellularis lateralis | 27.9 (2.8) | 48.8 (5.9) | 72.2 (7.1) | <0.001 | 58.3 (4.9) | 52% | <0.001 |
| Gigantocellularis | 34.5 (2.9) | 60.0 (6.3) | 76.2 (7.6) | <0.001 | 66.5 (5.0 | 48% | <0.001 |
| Intermediate reticular | 34.9 (2.9) | 61.4 (6.0) | 71.5 (7.3) | <0.001 | 65.5 (4.7) | 47% | <0.001 |
| Arcuate nucleus | 28.7 (3.2) | 33.6 (6.9) | 40.2 (8.3) | 0.410 | 36.4 (5.3) | 21% | 0.230 |
| Medullary 5-HT projection nuclei | |||||||
| Medial accessory olive | 37.6 (2.4) | 53.0 (6.2) | 46.2 (5.7) | 0.051 | 49.3 (4.2) | 24% | 0.020 |
| Nucleus of the solitary tract | 42.4 (2.3) | 80.5 (5.9) | 78.3 (5.4) | <0.001 | 79.3 (3.9) | 47% | <0.001 |
| Hypoglossal nucleus | 45.7 (3.2) | 81.2 (8.3) | 77.5 (7.6) | <0.001 | 79.1 (5.6) | 42% | <0.001 |
| Dorsal accessory olive | 33.6 (3.0) | 47.1 (6.4) | 73.5 (7.7) | <0.001 | NP | NP | NP |
| Principal inferior olive | 30.2 (2.3) | 43.3 (5.1) | 44.1 (6.1) | 0.021 | 43.6 (3.9) | 31% | 0.006 |
*
p value, comparison of SIDS and acute and chronic combined group; NP, not performed because the binding values for the acute and chronic controls were significantly different from each other.