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PGG glucan did not enhance 10-day survival in ovariectomized female mice or in ovariectomized female mice given a single dose of estrogen. Ovariectomized female mice (A) and ovariectomized female mice administered β-estradiol at the time of fluid resuscitation (B) were subjected to CLP and administered PGG glucan or dextran (10 mg/kg) 1 h after surgery. Survival was monitored over 10 days.
