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Reaction mechanism of the Slt70 LT proposed by Thunnissen et al. (259). R, d-lactoyl peptide. Step 1 is the cleavage of the MurNAc-(1→4)-GlcNAc bond with the formation of an oxocarbonium ion intermediate. Step 2 is an intramolecular nucleophilic attack on the C1 carbon of the oxocarbonium ion. Step 3 is the extraction of a proton by catalytic Glu478 and the formation of the 1,6-anhydro-MurNAc-peptide.
