Table 1.
E. coli peptidoglycan hydrolasesa
| Hydrolase | Gene | Localization | 3D structure reference | Substrate(s) |
|---|---|---|---|---|
| β-N-Acetylglucosaminidase NagZ | nagZ | C | SC + PG | |
| Lytic transglycosylases | ||||
| Slt70 | slt | P | 257 | PG |
| MltA | mltA | OM | 289 | SC + PG |
| MltB | mltB | OM | 277 | SC + PG |
| MltC | mltC | OM | PG | |
| MltD | mltD | OM | 9 | PG |
| MltE | mltE | OM | 3 | SC + PG |
| MltF | yfhD | OM | PG | |
| dd-Carboxypeptidases | ||||
| PBP4b | yfeW | CM | SC | |
| PBP5 | dacA | CM | 46 | SC + PG |
| PBP6 | dacC | CM | 36 | SC |
| PBP6b | dacD | CM | PG | |
| dd-Endopeptidases | ||||
| PBP7 | pbpG | P | PG | |
| MepA | mepA | P | 161 | SC + PG |
| EnvC | envC | CM/P | ||
| dd-Peptidases | ||||
| PBP4 | dacB | P | 125 | SC + PG |
| AmpH | ampH | CM | SC + PG | |
| ld-Carboxypeptidases | ||||
| LdcA | ldcA | C | SC | |
| 12 kDa | SC | |||
| 86 kDa | P | SC | ||
| ld-Transpeptidases | ||||
| ErfK | erfK | P | PG | |
| YbiS | ybiS | P | PG | |
| YcbB | ycbB | P | PG | |
| YcfS | ycfS | P | PG | |
| YnhG | ynhG | P | PG | |
| ld-Endopeptidase, 34 kDa | SC | |||
| Endoamidase MpaA | mpaA | C | SC | |
| MurNAc-l-Ala amidases | ||||
| AmiA | amiA | P | PG | |
| AmiB | amiB | P | PG | |
| AmiC | amiC | P | PG | |
| AmpD | ampD | C | 147 | SC |
| AmiD | amiD | OM | 124 | SC + PG |
| 39 kDa | P | SC | ||
| l-Ala-d/l-Glu epimerase YcjG | ycjG | C | 84 | SC |
| d-Ala-d-Ala dipeptidase DdpX | ddpX | C | 144 | SC |
a
dd-Peptidases show both dd-carboxypeptidase and dd-endopeptidase activities. C, cytoplasm; CM, cytoplasmic membrane; P, periplasm; OM, outer membrane; SC, soluble component (precursor, muropeptide, peptide, or glycan chain); PG, isolated PG.