Table 2.
Microbiologic clearance of carbapenem-resistant K. pneumoniae from urine, stratified by treatment cohort
| Characteristic | Cohort valuea |
P valueb | |||
|---|---|---|---|---|---|
| Aminoglycoside (n = 41) | Polymyxin B (n = 25) | Tigecycline (n = 21) | Untreated (n = 69) | ||
| Overall study population | 36 (88)c | 16 (64) | 9 (43) | 25 (36) | <0.001 |
| Associated pyuriad | 32/36 (89) | 13/21 (62) | 8/20 (40) | 11/42 (26) | <0.001 |
| Catheter associatede | 16/20 (80) | 8/13 (62) | 4/11 (36) | 9/30 (30) | 0.003 |
| Monotherapyf | 17/19 (89) | 3/7 (43) | 2/11 (18) | N/A | <0.001 |
| Susceptible to an aminoglycoside | 36/41 (88) | 8/10 (80) | 6/13 (46) | 15/41 (37) | <0.001 |
a
Data are the number(percentage) of cases for the overall study population and the number of cases/number of cases eligible (percentage) for subgroups. N/A, not applicable.
b
P values comparing all cohorts are based on the χ2 or Fisher's exact test.
c
The microbiologic clearance rate was 86% (25/29) for gentamicin and 92% (11/12) for amikacin.
d
Counts of >5 white blood cells/high-powered field on microscopic urinalysis.
e
Indwelling urinary catheter at the time of or within 48 h prior to the index culture.
f
Received ≤2 days of an accompanying inactive Gram-negative antimicrobial.