Skip to main content
. 2011 Dec;55(12):5861–5867. doi: 10.1128/AAC.05105-11

Table 1.

Pharmacokinetic parameters for FLBZ and its reduced metabolite (R-FLBZ) obtained in plasma and cystsa

Pharmacokinetic parameter Value for drugd
Plasma
Cysts
FLBZ R-FLBZ FLBZ R-FLBZ
AUC0–t (μg·h/ml[g]b) 1.80 ± 0.3 A 1.35 ± 0.3 A 0.35 ± 0.1 B 0.28 ± 0.1 B
Cmax (μg/ml[g]c) 1.56 ± 0.3 A 1.02 ± 0.1 B 0.12 ± 0.1 C 0.10 ± 0.0 C
Tmax (h) 0.30 ± 0.0 A 0.40 ± 0.1 A 0.10 ± 0.8 A 0.60 ± 0.3 A
Dp 5 min–6 h 5 min–6 h 5 min–6 h 5 min–6 h
a

AUC0–t, area under the concentration-versus-time curve from time zero to t; Cmax, peak plasma concentration; Tmax, time to Cmax; Dp, detection period. Different letters next to values indicate statistical differences in the pharmacokinetic parameter (P < 0.05).

b

Plasma AUC is expressed as μg·h/ml and cyst AUC as μg·h/g.

c

Plasma Cmax is expressed as μg/ml and cyst Cmax as μg/g.

d

Values are means ± SD for drug parameters after oral administration of FLBZ to mice (5 mg/kg).