Table 1.
Pharmacokinetic parameter | Value for drugd |
|||
---|---|---|---|---|
Plasma |
Cysts |
|||
FLBZ | R-FLBZ | FLBZ | R-FLBZ | |
AUC0–t (μg·h/ml[g]b) | 1.80 ± 0.3 A | 1.35 ± 0.3 A | 0.35 ± 0.1 B | 0.28 ± 0.1 B |
Cmax (μg/ml[g]c) | 1.56 ± 0.3 A | 1.02 ± 0.1 B | 0.12 ± 0.1 C | 0.10 ± 0.0 C |
Tmax (h) | 0.30 ± 0.0 A | 0.40 ± 0.1 A | 0.10 ± 0.8 A | 0.60 ± 0.3 A |
Dp | 5 min–6 h | 5 min–6 h | 5 min–6 h | 5 min–6 h |
AUC0–t, area under the concentration-versus-time curve from time zero to t; Cmax, peak plasma concentration; Tmax, time to Cmax; Dp, detection period. Different letters next to values indicate statistical differences in the pharmacokinetic parameter (P < 0.05).
Plasma AUC is expressed as μg·h/ml and cyst AUC as μg·h/g.
Plasma Cmax is expressed as μg/ml and cyst Cmax as μg/g.
Values are means ± SD for drug parameters after oral administration of FLBZ to mice (5 mg/kg).