Table 3.

Comparison of genetic content of resistance islands carrying fusB

Annotation or function	ORF no. or gene name of RIa					Orientation
	SeRIfusB-7778	SaRIfusB	SeRIfusB-2793	SeRIfusB-5907	SeRIfusB-704
Integrase	int	int	int	int	int	−
Hypothetical protein	1, 2	Absent	Absent	Absent	Absent	−
PI master repressor	3	1	1	1	1	−
Regulatory protein	4	2	2	2	2	+
Prophage antirepressor	Absent	Absent	3	3	Absent	+
Excisionase	Absent	3	4	4	3	+
Hypothetical protein	Absent	4	5	5	4	+
Hypothetical protein	Absent	5	Absent	Absent	Absent	+
Hypothetical protein	5	Absent	Absent	Absent	Absent	+
SaPIbov ORF-17-like protein	Absent	Absent	6	6	5	+
Hypothetical protein	Absent	Absent	7	7	6	+
Hypothetical protein	6	6	8	8	7	+
Bacteriophage resistance protein	Absent	Absent	9	9	8	+
Similar to DNA primase	7	7	Absent	Absent	Absent	+
Primase-polymerase	Absent	Absent	10	10	9	+
Replication initiator	8 (rep)	8 (rep)	Absent	Absent	Absent	+
Replication origin	ori	ori	Absent	Absent	Absent
Phage interference	Absent	9	Absent	Absent	Absent	+
Hypothetical protein	9	Absent	Absent	Absent	Absent	+
Hypothetical protein	10	10	Absent	Absent	Absent	+
Capsid size determinant	11	11	Absent	Absent	Absent	+
Capsid size determinant	12	12–14	Absent	Absent	Absent	+
Hypothetical protein	Absent	Absent	11–14	11–14	10–13	+
Hypothetical protein	13	Absent	Absent	Absent	Absent	+
Bacteriophage terminase small subunit	14 (terS)	15 (terS)	15 (terS)	15 (terS)	14 (terS)	+
Hypothetical protein	Absent	16	Absent	Absent	Absent	+
Hypothetical protein	Absent	Absent	16, 17	16, 17	15, 16	+
Pathogenicity island protein	Absent	Absent	18	18	17	+
Hypothetical protein	ri17	ri17	ri17	ri17	ri17	+
Hypothetical protein	ri18	ri18	ri18	ri18	ri18	+
Hypothetical protein	Δaj1	aj1	aj1	Δaj1	Δaj1	−
fusB leader peptide	LP	LP	LP	LP	LP	+
Fusidic acid resistance gene	fusB	fusB	fusB	fusB	fusB	+
Hypothetical protein	Absent	17	Absent	Absent	Absent	+
Hypothetical protein	Absent	18	Absent	Absent	Absent	+
Transposase	Absent	19	Absent	Absent	Absent	−
Hypothetical protein	Absent	Absent	Absent	Absent	aj2	+
Hypothetical protein	Absent	Absent	Absent	Absent	Δaj3	+

^aSaRI, Staphylococcus aureus resistance island (23); SeRI, Staphylococcus epidermidis resistance island.