Table 2.

Noncompartmental pharmacokinetic parameters for meropenem (0.5 g) and biapenem (0.3 g) after a 0.5-h infusion (mean ± SD; n = 8)

Sample type and parameter	Value
	Meropenem	Biapenem
Plasma
AUC0–∞ (mg-h/liter)	54.90 ± 7.49	38.93 ± 8.77
AUC5.5–∞ (% of AUC0–∞)	3.9 ± 1.7	6.4 ± 1.8
Cmax (mg/liter)	39.71 ± 7.84	20.84 ± 4.26
Tmax (h)	0.5	0.5
CLtotal (liters/h)	9.27 ± 1.38	8.01 ± 1.58
Vsteady state (liters)	13.47 ± 2.10	13.40 ± 2.16
Bile
AUC0–∞ (mg-h/liter)	21.07 ± 8.82	11.46 ± 3.75
AUC5.5–∞ (% of AUC0–∞)	6.2 ± 3.7	7.9 ± 2.8
Cmax (mg/liter)	9.72 ± 3.54	4.82 ± 1.21
Tmax (h)	1.31 ± 0.44	1.31 ± 0.22
Both sample types
AUC0–∞, bile/AUC0–∞, plasma	0.38 ± 0.15	0.30 ± 0.11
Cmax, bile/Cmax, plasma	0.25 ± 0.10	0.24 ± 0.08