Table 2.
Bayesian posterior density results and AUCELF,0-∞/AUCplasma,0-∞ penetration ratios for 10 subjects included in the analysis
| Subject | Vc (liters) | SCL (liters/h) | K12 (h−1) | K21 (h−1) | K13 (h−1) | K31 (h−1) | VELF (liters) | ELF/plasma penetration ratio |
|---|---|---|---|---|---|---|---|---|
| 1 | 10.12 | 4.404 | 0.34 | 0.22 | 3.77 | 5.65 | 20.49 | 0.33 |
| 2 | 5.51 | 8.64 | 1.72 | 2.19 | 11.00 | 5.90 | 2.15 | 4.77 |
| 3 | 9.09 | 6.84 | 1.00 | 0.28 | 6.36 | 15.98 | 5.82 | 0.62 |
| 4 | 11.57 | 6.41 | 0.98 | 0.38 | 6.31 | 15.03 | 7.62 | 0.64 |
| 5 | 11.72 | 6.25 | 0.90 | 0.35 | 3.72 | 15.81 | 10.38 | 0.27 |
| 6 | 6.07 | 9.22 | 0.37 | 0.25 | 12.50 | 8.19 | 15.72 | 0.59 |
| 7 | 9.02 | 4.78 | 0.76 | 0.30 | 2.52 | 7.57 | 12.46 | 0.24 |
| 8 | 9.02 | 4.79 | 0.76 | 0.30 | 2.52 | 7.58 | 12.46 | 0.24 |
| 9 | 10.09 | 4.40 | 0.34 | 0.21 | 3.80 | 5.72 | 20.40 | 0.33 |
| 10 | 6.79 | 5.11 | 1.77 | 0.36 | 7.88 | 16.17 | 7.48 | 0.44 |
Vc, volume of the central compartment; K12, K21, K13, and K31, first-order intercompartmental transfer rate constants; SCL, serum clearance; VELF, volume of ELF.