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Time-kill studies of A. fumigatus conidia exposed to free or cell-associated posaconazole. A. fumigatus conidia were incubated with free posaconazole or A549 cells exposed to posaconazole at the indicated concentrations. At the indicated time intervals, conidia were collected, washed to remove posaconazole, and then quantitatively cultured in drug-free medium.
