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. 2011 Dec;55(12):5868–5873. doi: 10.1128/AAC.00424-11

Fig. 3.

Fig. 3.

Simulation data for the probability of target attainment (PTA) following fluconazole dosing in patients receiving CVVHDF. The dosing schedules included loading doses (LD) ranging from 200 mg to 1,600 mg (A and D), a standard dose of 200 mg twice daily following the range of LD (B and E), and the effect of CVVHDF treatment relative to that of patients with normal renal function (C and F). A PTA of 1.0 was defined when fAUC/MIC ratios exceeded 25 (A to C) and 100 (D to F). Parameters for patients with normal renal function were obtained from reference 31.