Table 2.
Population parameter estimates for the final fluconazole CVVHDF model and the 1,000 bootstrap runs
| Parameter | Description | Unit | CVVHDF model estimate | 1,000 bootstrap replicates |
|
|---|---|---|---|---|---|
| Median | 95th percentileb | ||||
| CLCVVHDF | Clearance of fluconazole by CVVHDF | Liters/h | 1.66 | 1.65 | 1.45–1.92 |
| CLNCVVHDF | Non-CVVHDF clearance of fluconazole | Liters/h | 1.01 | 0.95 | 0.42–1.56 |
| Vc | Central vol of distribution | Liters | 31.7 | 29.8 | 9.3–47.0 |
| Q | Intercompartmental clearance | Liters/h | 27.6 | 30.8 | 5.4–70.1 |
| Vp | Peripheral vol of distribution | Liters | 21.9 | 23.9 | 15.0–38.5 |
| D1 | Duration of intravenous infusion | h | 0.689 | 0.701 | 0.570–0.885 |
| ffCLCVVHDF | Effect of filter in use >48 h on CLCVVHDF | 0.368 | 0.368 | 0.326–0.426 | |
| BSV CLCVVHDF | Between-subject variability in CLCVVHDF | CVa | 19.8 | 18.6 | 9.90–26.3 |
| BSV CLNCVVHDF | Between-subject variability in CLNCVVHDF | CV | 77.1 | 78.0 | 20.5–156 |
| BSV Vc | Between-subject variability in VC | CV | 22.9 | 23.8 | 8.40–93.5 |
| BSV D1 | Between-subject variability in D1 | CV | 23.0 | 20.3 | 0–55.1 |
| RUVSDP | Additive residual error in plasma | mg/liters | 0.239 | 0.233 | 0–0.410 |
| RUVCVP | Exponential residual error in plasma | CV | 3.67 | 3.73 | 0–6.67 |
| RUVSDC | Additive residual error in CVVHDF | mg/liters | 2.84 | 2.77 | 1.31–3.71 |
a
CV, coefficient of variation (%).
b
2.5th and 97.5th percentile range.