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Key polar interactions observed with crystallographic structures between CTX-M-9-S70G and piperacillin (A), benzylpenicillin (B), cefotaxime (C), hydrolyzed piperacillin (D), and hydrolyzed benzylpenicillin (E). Carbon atoms are in green for the protein or in yellow for the adduct; oxygen atoms are red, and nitrogen atoms are blue. The α-carbon of the carbonyl of the side chain of β-lactams is magenta.
