Table 1.
Demographic characteristics of children (study A) and adults (study B)
| Characteristic | Children (n = 40) | Adults (n = 35) |
|---|---|---|
| Gender (race) | ||
| No. of males (no. of race [white/black/other]) | 23 (14/6/3) | 24 (20/3/1) |
| No. of females (no. of race [white/black/other]) | 17 (10/5/2) | 11 (10/0/1) |
| Age | ||
| No. aged 2–<6 yr | 24 | |
| No. aged 6–<12 yr | 16 | |
| Mean age (yr) (SD) | 5.4 (3.0) | 35.3 (7.8) |
| Median age (yr) (range) | 5.0 (2–11) | 34 (22–55) |
| Wt | ||
| No. weighing ≤20 kg | 21 | |
| No. weighing >20 kg–≤40 kg | 13 | |
| No. weighing >40 kg | 6 | |
| Mean wt (kg) (SD) | 22.9 (12.2) | 75.1 (11.2) |
| Median wt (kg) (range) | 18.9 (10.8–54.5) | 76.0 (49.0–97.0) |
| No. with CYP2C19 genotyping statusa | ||
| UM | 2 | |
| EM | 11 | 20 |
| HEM | 22 | 14 |
| PM | 1 | 1 |
| Unknown | 4 |
a
UM, ultra rapid extensive metabolizer; EM, homozygous extensive metabolizer; HEM, heterozygous extensive metabolizer; PM, poor metabolizer.