Fig. 4.
Results of a primary screen with 17 compounds identified by ATP similarity searches and virtual docking. All compounds were screened at 10 μM, and parasite growth was measured after 3 days of treatment. One compound (F1792-0016) inhibited parasite growth by 96% ± 0.14% (P = 4.63 × 10−8). In addition, F0920-5744 mildly inhibited growth by 40.60% ± 4.73% (P > 0.05), but upon visual inspection it was found to be toxic to the host cells. ST055366 mildly enhanced parasite growth by 188.60% ± 22.82% (P > 0.05), while ST056006 was mildly inhibitory, at 23.93% ± 6.41% (P > 0.05). ST056006 and ST055366 are identical except for two switched functional groups (Fig. 2).