Table 1.

Enriched GO terms in Toxoplasma transcripts with either higher or lower abundance after 48 h of treatment with 2 μM F1792-0016

Gene ontology term	Population frequency	Study frequency	P valuea	Description	No. of differentially expressed genes	F1792-0016 effect on transcript levels
0006886	0.0329	0.1069	2.0E−06	Intracellular protein transport	28	Lower
0016192	0.0233	0.0878	2.1E−06	Nonselective vesicle transport	23	Lower
0004298	0.0093	0.0534	4.3E−06	Prosome	14	Lower
0005839	0.0093	0.0534	4.3E−06	Macropain	14	Lower
0008565	0.0115	0.0534	1.1E−04	Protein transporter activity	14	Lower
0030117	0.0103	0.0458	1.2E−03	Membrane coat	12	Lower
0008094	0.0034	0.0267	1.3E−03	DNA-dependent ATPase activity	7	Lower
0016021	0.0547	0.1221	1.8E−03	Integral to membrane	32	Lower
0005741	0.0012	0.0153	1.0E−02	Outer mitochondrial membrane	4	Lower
0004748	0.0012	0.0153	1.0E−02	Ribonucleoside diphosphate reductase activity	4	Lower
0008308	0.0012	0.0153	1.0E−02	Voltage-gated anion channel activity	4	Lower
0004175	0.0031	0.0229	1.1E−02	Proteinase	6	Lower
0006511	0.0227	0.0649	1.2E−02	Ubiquitin-dependent protein catabolic process	17	Lower
0015031	0.0149	0.0496	1.8E−02	Protein transport	13	Lower
0051603	0.0047	0.0267	1.9E−02	Proteolysis during cellular protein catabolic process	7	Lower
0016020	0.1603	0.2443	3.9E−02	Membrane	64	Lower
0006820	0.0016	0.0153	4.9E−02	Anion transport	4	Lower
0000786	0.0043	0.0574	2.5E−05	Nucleosome	7	Higher
0006334	0.0053	0.0574	1.3E−04	Nucleosome assembly	7	Higher
0004672	0.0957	0.2295	6.0E−04	Protamine kinase activity	28	Higher
0006468	0.0966	0.2295	7.3E−04	Protein amino acid phosphorylation	28	Higher
0003723	0.0503	0.1311	3.0E−02	RNA binding	16	Higher

^aBonferroni-corrected P value based on the number of GO categories in the study population.