Table 5.
Influence of HIV, type of TB, RMP, gender, age and nutritional status (weight for age Z score) on pharmacokinetic parameters of RMP
| Parameter | N |
Cmax(μg/ml) |
tmax (h) |
AUC0-5(μg·h/ml) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 mg/kg |
15 mg/kg |
10 mg/kg |
15 mg/kg |
10 mg/kg |
15 mg/kg |
||||||||
| Mean (95% CI) | P valuea | Mean (95% CI) | P valuea | Mean (95% CI) | P valuea | Mean (95% CI) | P valuea | Mean (95% CI) | P valuea | Mean (95% CI) | P valuea | ||
| HIV status | |||||||||||||
| Negative | 7 | 6.85 (4.43-9.27) | 0.520 | 12.52 (7.65-27.39) | 0.350 | 1.612 (0.97-2.25) | 0.390 | 1.56 (0.88-1.38) | 0.901 | 18.41 (12.80-24.02) | 0.774 | 36.12 (22.67-49.57) | 0.810 |
| Positive | 4 | 5.49 (0.06-10.92) | 10.24 (6.46-14.01) | 1.283 (0.48-2.08) | 1.52 (1.38-1.66) | 16.68 (0.24-33.12) | 38.40 (15.21-61.59) | ||||||
| Type of TB | |||||||||||||
| Extrapulmonary | 8 | 5.77 (3.23-8.31) | 0.185 | 11.49 (7.19-15.80) | 0.753 | 1.62 (1.09-2.15) | 0.271 | 1.54 (0.97-2.11) | 0.998 | 17.16 (10.10-24.23 | 0.576 | 37.29 (23.97-50.62 | 0.870 |
| Pulmonary | 3 | 7.93 (3.66-12.20) | 12.21 (6.77-17.66) | 1.14 (0.17-2.46) | 1.54 (1.32-1.77) | 19.44 (8.70-30.19) | 36.03 (15.40-56.67) | ||||||
| Gender | |||||||||||||
| Male | 6 | 6.20 (3.81-8.60) | 0.866 | 12.20 (9.09-15.31) | 0.724 | 1.50 (1.43-1.57) | 0.961 | 1.31 (0.87-1.75) | 0.176 | 18.19 (11.28-25.09) | 0.860 | 37.51 (28.27-46.75) | 0.901 |
| Female | 5 | 6.53 (1.96-11.12) | 11.09 (3.50-18.67) | 1.48 (0.26-2.70) | 1.82 (1.01-2.63) | 17.30 (6.03-28.57) | 36.28 (12.01-60.55) | ||||||
| Age | 11 | 0.240 | 0.232 | 0.351 | 0.153 | 0.415 | 0.527 | ||||||
| Nutritional status (Z score wt for age) | 11 | 0.344 | 0.774 | 0.437 | 0.217 | 0.832 | 0.270 | ||||||
a
P values are from independent t test (HIV, TB, RMP, gender) or linear regression analysis (age, nutrition).