Table 4.

MICs of different antifungals against Aspergillus fumigatus and A. lentulus isolates and their derived mutant strains

Isolate	Origin and/or background	Species	cyp5A gene copy origin	MIC (μg/ml)
				AmB	ITC		VCZ		POS
				EUCAST	EUCAST	Etest	EUCAST	Etest	EUCAST	Etest
CM-1290	Sputum	A. lentulus	A. lentulus	1–4	0.5–8	8–32	4	4–6	012–0.25	1
ATCC 2004305	Reference strain	A. fumigatus	A. fumigatus	0.25–0.5	0.12–0.25	2	0.25–0.5	0.25	0.03–0.12	0.19
akuBKU80	BALa	A. fumigatus	A. fumigatus	0.25–0.5	0.12–0.25	1.5–4	0.25	0.38–0.25	0.03–006	0.012–0.38
CM-237	Sputum	A. fumigatus	A. fumigatus	0.25–0.5	0.25	0.75–3	0.25–0.5	012–0.19	0.06–012	0.012–0.38
CM237-A-8	Mutant; CM237	A. fumigatus	Δcyp51A	0.5	0.03	0.047	0.12	0.064	0.015	<0.02
CM1290-T29.18	Mutant; CM1290	A. lentulus	Δcyp51A	2–4	0.03–0.06	0.032–0.064	0.25	0.064	0.015	0.064
Mutant T52.7	Mutant; akuBKU80	A. fumigatus	A. lentulus	0.25	0.5–8	8–32	2	2–4	0.25	0.25–1.5
Mutant T52.8	Mutant; akuBKU80	A. fumigatus	A. lentulus	0.25	0.25	4	1	1–2	0.06–0.12	1
Mutant T52.9	Mutant; akuBKU80	A. fumigatus	A. lentulus	0.25	0.5	8	1	1–3	0–12	0.5–1

^aBAL, bronchoalveolar lavage.