Fig. 4.
Geometric means of ATV exposures (AUC, Cmax, and Cmin). Model-based simulations were conducted to evaluate a comprehensive set of weight-tiered ATV capsule doses for pediatric patients weighing ≥15 kg to determine optimal RTV-boosted ATV capsule dose recommendations for pediatric patients. The proposed, weight-based ATV doses are labeled by crosses. The vertical dashed line in each panel represents the respective target adult exposure (80% and 125% of adult GM AUC, 150% of adult GM Cmax, and 75% of adult GM Cmin).