Table 4.
Final model parameter estimates
| Parametera | Mean estimate ± SE | IIV (%) | IOV (%) |
|---|---|---|---|
| Ka (1/h) | 2.04 ± 0.31 | 173 | |
| Age ∼ Ka | −0.822 ± 0.139 | ||
| Ke (1/h) | 0.130 ± 0.006 | 14.6 | 22.2 |
| V/F (liters) | 266 ± 25 | 42.5 | |
| Body wt ∼ V/F | 0.706 ± 0.082 | ||
| CL/F (liters/h) | 34.6 | ||
| Region (Africa) ∼ CL/F | 0.145 ± 0.045 | ||
| Body wt ∼ CL/F | 0.600 ± 0.083 | ||
| Sex (female) ∼ CL/F | −0.115 ± 0.035 | ||
| Comedication (with RTV) ∼ CL/F | −0.409 ± 0.026 | ||
| tlag (h)b | 0.913 ± 0.002 | ||
| C0 (ng/ml) | 118 | ||
| ATV | 158 ± 17 | ||
| ATV + RTV | 672 ± 61 | ||
| Frel | 1 | ||
| Formulation (powder) ∼ Frel | −0.355 ± 0.100 | 88.8c | |
| Comedication (with RTV) ∼ Frel | 1.32 ± 0.24 | 59.4d | |
| Residual error (%CV) | |||
| ATV | 55.2 | ||
| ATV + RTV | 35.3 |
a
Covariate ∼ PK parameter, covariate effect on PK parameter.
b
Absorption lag time.
c
Interoccasion variability of Frel for ATV alone.
d
Interoccasion variability of Frel for ATV in combination with RTV.