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. 2011 Dec;55(12):5541–5546. doi: 10.1128/AAC.05149-11

Fig. 4.

Fig. 4.

Effect of L-NAME on rifampin stimulation of IL-8 production. (a) HepG2 cells were treated with rifampin in the presence or absence of L-NAME (NOS inhibitor) (20 μM). IL-8 levels were determined 24 h after stimulation. P < 0.007 for rifampin at 50 mg/liter versus rifampin at 50 mg/liter + L-NAME; P < 0.006 for rifampin at 10 mg/liter versus rifampin at 10 mg/liter + L-NAME) (n = 4). Data represent the results of one of three similar experiments. (b) IL-8 mRNA expression 19 h after the addition of rifampin with or without L-NAME (20 μM). The values represent changes compared with the results determined for the control untreated cells. Data are presented as the means ± standard errors of the means. P < 0.04 for rifampin at 10 mg/liter versus rifampin at 10 mg/liter + L-Name and for rifampin at 50 mg/liter versus rifampin at 50 mg/liter + L-NAME) (n = 3).