Fig. 3.

In vitro antimalarial activity of cyclopropyl carboxamides in the different intraerythrocytic stages of P. falciparum. Ring-enriched cultures of strain 3D7 were treated as described in Materials and Methods. Treated parasites were followed during an entire life cycle, and effects were checked by microscopy. Numbers of observed red blood cells (RBC), rings (R), and trophozoites (T) are indicated. P is parasitemia expressed as a percentage. Cyclopropyl carboxamides stop further progression of trophozoites through the life cycle.