Table 1.
Compound | IC50 (μM)a for P. falciparum strain: |
|||||
---|---|---|---|---|---|---|
3D7A | K1 | DD2 | HB3 | FCR3 | TM90C2B | |
GSK1057714A | 0.103 | 0.129 | 0.102 | 0.164 | 0.142 | 0.076 |
GSK2645947A | 0.003 | NTb | 0.002 | 0.005 | 0.007 | 0.004 |
Atovaquone | 0.002 | 0.002 | 0.003 | 0.001 | 1.372 | >5 |
Artemisinin | 0.029 | 0.019 | 0.031 | 0.028 | 0.014 | 0.030 |
Chloroquine | 0.024 | 0.796 | 0.558 | 0.027 | 0.341 | 0.564 |
All results are the means of at least three independent experiments.
NT, not tested.