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. 2011 Dec;55(12):5740–5745. doi: 10.1128/AAC.05188-11

Table 1.

In vitro antimalarial activities of cyclopropyl carboxamides against different P. falciparum strains

Compound IC50 (μM)a for P. falciparum strain:
3D7A K1 DD2 HB3 FCR3 TM90C2B
GSK1057714A 0.103 0.129 0.102 0.164 0.142 0.076
GSK2645947A 0.003 NTb 0.002 0.005 0.007 0.004
Atovaquone 0.002 0.002 0.003 0.001 1.372 >5
Artemisinin 0.029 0.019 0.031 0.028 0.014 0.030
Chloroquine 0.024 0.796 0.558 0.027 0.341 0.564
a

All results are the means of at least three independent experiments.

b

NT, not tested.