Table 5.

In vitro antimalarial activities of cyclopropyl carboxamides against selected resistant clones

Compound	IC50 (μM)a for P. falciparum:
	3D7Ab	Clone E2	Clone E3	Clone C3	Clone C7
GSK1057714A	0.047	>5	>5	>5	1.640
GSK2645947A	0.002	0.385	0.436	0.369	0.147
GSK2611622A	0.020	2.241	2.366	2.486	1.236
GSK2661685A	0.052	>5	>5	>5	2.766
GSK2678892A	0.146	4.862	ND	ND	4.533
Atovaquone	0.003	0.005	0.004	0.005	0.004
Artemisinin	0.027	0.026	0.024	0.027	0.022
Chloroquine	0.027	0.031	0.031	0.033	0.029
Pyrimethamine	0.072	0.050	0.058	0.055	0.037

^aResults are the means of three independent experiments.

^bWild type.