Table 3.

Top 10 homologous structures to the crystal structure of CT296 as measured by PSFloger and DALI

Rank	PSFloger					DALI
	TM-scorea	PDB file	Protein name	Species	Classification (reference)	Z-scoreb	PDB file	Protein name	Species	Classification
1	0.7806	2OPW	PHYHD1	Homo sapiens	Hydroxylase (37)	10.5	2OPW	PHYHD1c	Homo sapiens	Hydroxylase (37)
2	0.7537	2FCU	SyrB2	Pseudomonas syringae	Halogenase (4)	10.5	3GJB	CytC3	Streptomyces sp.	Halogenase (60)
3	0.7473	2A1X	PHYHD1	Homo sapiens	Hydroxylase (34)	10.3	3NN1	Hal	Nitrospira defluvii	Halogenase (25)
4	0.7221	2CSG	YbiU	S. enterica serovar Typhimurium	Putative oxidoreductase	9.9	3EMR	ECTD	Virgibacillus salexigens	Dioxygenase (43)
5	0.7138	2DBN	JW0805	Escherichia coli	Unknown function	9.7	3HQU	PHD2c	Homo sapiens	Hydroxylase (7)
6	0.7113	2HBT	PHD2	Homo sapiens	Hydroxylase (58)	9.4	2FCU	SyrB2	Pseudomonas syringae	Halogenase (4)
7	0.6905	1UNB	DAOCS	Streptomyces clavuligerus	Oxidoreductase (55)	9.1	3GZE	P4Hc	Chlamydomonas reinhardtii	Hydroxylase (29)
8	0.6802	2RDN	PtlH	Streptomyces avermitilis	Hydroxylase (65)	9.0	2RG4	Q2CBJ1_9RHOB	Oceanicola granulosus	Unknown function
9	0.6793	3GJB	CytC3	Streptomyces sp.	Halogenase (60)	8.8	3MGU	Tpa1	Saccharomyces cerevisiae	Hydroxylase (27)
10	0.6764	1GP6	ANS	Arabidopsis thaliana	Dioxygenase (59)	8.7	3ITG	PutA	Escherichia coli	Oxioreductase (46)

^aThe TM-score is a measurement of similarity between two protein structures, and it varies from 0 to 1, with 1 indicating a perfect alignment. A score of 0.5 or higher indicates significant similarity (69).

^bStructures with Z-scores above 2 are considered to be significant matches (20).

^cThis protein was listed multiple times on the DALI output, with various minor differences (ligands, etc.); the redundant structures are not listed here.