Table 2.
Effects of DNMT1 deacetylation mutations
| DNMT1 mutant | Increase in enzymatic activity | Decrease in transcription repression | Decrease in SIRT1 binding | Inability to relieve G2/M arrest |
|---|---|---|---|---|
| 2KR | + | − | − | − |
| DR | − | + | − | − |
| 16KR | + | + | + | + |
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