Table 2.
Patient demographics including mycobacterial therapy and environmental isolates of M. porcinum from UTMB (September 2005 through September 2010)a
| Patient | Isolate, MF no. | Age (yr) | Sex | Source (no. of positive cultures/no. tested) | Date of collectionb | PFGE pattern |
Underlying disease or condition | Antimycobacterial treatment | |
|---|---|---|---|---|---|---|---|---|---|
| XbaI | AseI | ||||||||
| Pulmonary | |||||||||
| 1 | 2817 | 58 | M | Sputum (2/3) | 1/1/07 | B3 | B2 | COPD (no CT) | None |
| 2 | 2763 | 42 | F | Sputum (3/3) | 7/4/06 | A | A | COPD, HIV infection, hemoptysis, multiple lung nodules (CT, 7/14/10) | DOX + CLA × 4 mo, CIP × 2 mo |
| 3 | 3112 | 56 | F | Sputum (1/1) | 10/22/08 | A | A2 | Perihilar infiltrate (no CT) | None |
| 4 | 2987 | 47 | M | Sputum (2/3) | 1/24/08 | B3 | B | Necrotizing MRSA pneumonia, porphyria cutanea tarda, no bronchiectasis, no nodules (CT, 1/21/08) | Levo × 2 wk, SXT × 2 wk |
| 5 | 3054 | 70 | M | Sputum (2/3 | 6/23/08 | B3 | B | COPD, lung cancer (CT, 6/20/08 | None |
| 6 | 2983 | 32 | M | Bronchoalveolar lavage (2/4) | 12/14/07 | B4 | B2 | Hypogammaglobulinemia, necrotizing pneumonia, multiple lung nodules (CT, 12/13/07) | None |
| 7 | 3075 | 64 | F | Sputum (2/3) | 7/7/08 | B3 | B | Multiple lung nodules, AIDS, disseminated MAC (CT, 7/21/08) | None |
| 8 | 2629 | 75 | F | Sputum (2/2) | 10/17/05 | A | A3 | COPD, necrotizing pneumonia; bilateral upper lobe cavities; multiple small nodules (stable) (CT, 9/6/05) | CIP + SXT × 2 wk, CIP × 9 mo |
| 9 | 3084 | 67 | F | Sputum (2/2) | 8/6/08 | B3 | B2 | Lung cancer, postobstruction pneumonia, no nodules or bronchiectasis (CT, 7/17/08) | AMI + FOX + DOX × 14 days/DOX + CLA |
| 10 | 2672, #1 | 58 | M | Sputum | 1/31/06 | A | A4 | AIDS, hazy infiltrates, mediastinal lymphadenitis, no nodules or bronchiectasis (CT, 3/03/06) | CIP + CLA × 6 mo |
| 10 | 2672, #2 | Sputum (4/6) | 3/15/06 | A2 | A2 | ||||
| 11 | 2989 | 60 | F | Sputum (1/4) | 1/11/08 | A3 | A2 | Rheumatoid arthritis, bronchiectasis, pneumonia (CT, 1/12/08) | SXT + MIN × 10 days |
| 12 | 2602, #2 | 81 | F | Sputum (2/2) | 7/18/08 | A5 | A5 | Bronchiectasis, multiple lung nodules, chronic Pseudomonas (CT, 8/08/08) | CIP × 9 mo, CLA + CIP × 2 mo |
| 13 | 2977 | 53 | M | Sputum (1/1) | 11/27/07 | B3 | B | AIDS, pneumonia, no nodules or bronchiectasis (CT, 11/27/07) | Levo × 7 days, SXT × 21 days |
| 14 | 2978 | 55 | M | Sputum (6/7) | 1/1/08 | B3 | B | Pulmonary embolus; LLL pneumonia, bronchiectasis, bullous emphysema (CT, 12/31/07) | CIP + CLA + SXT (unknown duration) |
| 15 | 3449 | 79 | M | Sputum (1/3) | 5/24/10 | A | B3 | Hemoptysis, metastatic adenocarcinoma of lung, no nodules or bronchiectasis (CT, 5/22/10) | None |
| 16 | 3452 | 50 | M | Sputum (1/4) | 6/12/10 | A | B3 | Staphylococcal pneumonia, bilateral pleura effusions, diabetes (CT, 6/11/10) | Vancomycin (5 days), oral DOX (4 wk) |
| 17 | 3460 | 41 | M | Sputum (4/4) | 8/4/10 | A | B3 | Pneumococcal, necrotizing pneumonia, loculated lung abscess, empyema (CT, 8/4/10) | Levo (2 wk), metronidazole (2 wk), vancomycin (4 days) |
| 17 | 3469 | 8/5/10 | A | B3 | |||||
| 17 | 3470 | 8/6/10 | A | B3 | |||||
| 17 | 3471 | 8/8/10 | A5 | A2 | |||||
| Extrapulmonary | |||||||||
| 18 | 2612, #1 | 17 | F | Spinal wound | 10/28/05 | C | C | Thoracolumbar scoliosis, Harrington rods inserted (UTMB 7/05); postoperative spinal epidural abscesses | Removal of hardware, SXT (unknown duration) |
| 18 | 2612, #2 | 20 | F | Paraspinal tissue | 12/16/07 | C | C | Same as above | Surgical debridement (unknown duration) |
| 19 | 2875 | 38 | F | Port exit site | 5/9/07 | A | A3 | Port infection; cancer, chemotherapy, UTMB hospitalization 1 mo earlier | Port removal |
| 20 | 3082 | 33 | M | Neck fluid | 8/1/08 | D | D | HIV infection, neck abscess | Abscess drainage |
| 21 | 3036 | 35 | F | Blood, catheter tip | 5/24/08 | B4 | B3 | Sickle cell disease, port infection; UTMB hospitalization, 2 mo earlier | Port removal, CIP + SXT + CLA × 1 mo |
| 22 | 2721 | 36 | F | Breast fluid | 5/25/06 | A6 | A | Breast abscess | Drainage |
| 23 | 3019 | 58 | F | Peritoneal fluid | 3/21/08 | B3 | B | Hepatocellular cancer, gastric perforation with polymicrobial peritonitis | Peritoneal fluid drainage |
| 24 | 3451 | 63 | M | Finger nodule | 3/18/10 | A | A | Biopsy had granulomatous inflammation, AFB smear positive | Excision |
| Environmental | |||||||||
| 3130 | Hospital water | 10/30/08 | A | A | |||||
| 3131 | Hospital water | 10/30/08 | A | A2 | |||||
| 3132 | Hospital ice machine | 10/30/08 | A3 | B | |||||
| 3128 | Hospital water | 10/31/08 | A2 | A2 | |||||
| 3129 | Hospital water | 10/28/08 | A2 | A | |||||
| 3546 | Household 1 | 02/11 | A | A | |||||
| 3547 | Household 1 | 02/11 | U | U | |||||
| 3548 | Household 2 | 02/11 | A | A | |||||
| 3549 | Household 3 | 02/11 | A | A | |||||
| 3550 | Household 5 | 02/11 | U | U | |||||
a
CIP, ciprofloxacin; SXT, trimethoprim-sulfamethoxazole; MAC, M. avium complex; MIN, minocycline; Levo, levofloxacin; DOX, doxycycline; FOX, cefoxitin; CLA, clarithromycin; AMI, amikacin; LLL, lower left lobe; MRSA, methicillin-resistant Staphylococcus aureus; COPD, chronic obstructive pulmonary disease.
b
Dates are expressed as month/day/year. See also the dates for CT analyses in column 9.