Table 2.
Molecular characteristics of 36 MRSA bloodstream isolates recovered from renal patients between 2005 and 2009
| ST | SCCmec type (n) | spa type(s) (n) | agr/capsule types | Antimicrobial resistance genesa | Virulence-associated genesa | MSCRAMM, adhesion, and biofilm genesa |
|---|---|---|---|---|---|---|
| 22 | IV (27) | t025 (1), t032 (12), t515 (3), t557 (3), t1214 (3), t2945 (2), t3185 (1), t5420 (1), t7636 (1) | I/5 | erm(C) (21), lnu(A), aacA-aphD, aadD, mupA (1) | seb (2), sec/l (16), egc, sak-chp-scn (22; IEC type B), ACME (1) | bbp (25), cna, map, sdrC, sdrD (26), sasG |
| 5 | II (5) | t463 (5) | II/5 | erm(A), aadD, tetefflux, fosB, merA, merB (1) | tst, sed/j/r, egc, sea-sak-chp-scn (IEC type A) | bbp, ebh, fib, fnbB, map, sdrC, sdrD, sasG |
| 8 | IIE and ccrAB4 (2), novel II subtype (1)b | t190 (3) | I/5 | erm(A), tetefflux, fosB, qacA, aacA-aphD, aadD, aphA3-sat (2), merA, merB (2) | sea-sak-scn (IEC type D) | bbp, ebh, fib, fnbB (2), map (2), sdrD |
| 30 | IV (1) | t1662 (1) | III/8 | Q6GD50 (fusC), tetefflux, fosB | tst, egc, sak-chp-scn (IEC type B) | bbp, cna, ebh, fib, map, sdrC, sdrD |
a
The number of positive isolates is indicated in parentheses if not all isolates within a genotype were positive for the gene indicated. All isolates harbored the beta-lactamase resistance gene blaZ and the MSCRAMM, adhesion, and biofilm genes icaA, icaC and icaD, cl6fA and clfB, ebpS, eno, fnbA, and vwb.
b
Possible novel SCCmec II subtype identified in one ST8 MRSA isolate that yielded signals for class A mec complex ccrAB2 but lacked signals for kdp and aadD(pUB110).