Table 1.

Clinical characteristics, radiological findings, and results of GM and PCR assays for 17 patients with proven and probable IA

Patient no.	Clinical setting	IA diagnosisa	Underlying disease/host factor(s)b	CT finding(s)	BAL fluid result		GM OD index		CT result
					Microscopy	Culture	Serum	BAL fluidc	MycAssayd	In-house PCR
1	ICU	Probable	Cirrhosis	Nodules	Negative	Negative	1.2	1.8	Positive (33.5)	Positive (34.2)
2	HEM	Probable	AML	Nodules	Positive	Positive (A. fumigatus)	2.1	5.5	Positive (25.4)	Positive (27.2)
3	HEM	Probable	ALL	Air crescent sign	Negative	Negative	0.9	2.2	Positive (32.5)	Positive (33.4)
4	HEM	Probable	AML	Halo	Negative	Negative	0.8	0.4	Positive (32.5)	Positive (35.1)
5	ICU	Probable	Steroids	Pleural effusion	Negative	Negative	1.8	3.2	Positive (31.5)	Positive (30.9)
6	ICU	Probable	Steroids, COPD	NAe	Positive	Negative	2.2	2.9	Positive (30.9)	Positive (31.8)
7	HEM	Probable	AML	Nodules	Negative	Negative	1.5	2.3	Positive (33.3)	Negative
8	HEM	Probable	ALL	Air crescent sign	Positive	Positive (A. fumigatus)	3.5	6.3	Positive (24.4)	Positive (26.0)
9	HEM	Probable	AML	Nodules, halo	Positive	Positive (A. fumigatus)	2.9	7.0	Positive (27.2)	Positive (27.9)
10	HEM	Provenf	AML	Halo	Positive	Positive (A. flavus)	1.8	8.3	Positive (21.5)	Positive (24.1)
11	HEM	Probable	NHL	Nodules	Negative	Negative	0.8	1.9	Positive (29.8)	Positive (30.2)
12	HEM	Probable	ALL	Nodules	Positive	Positive (A. fumigatus)	1.3	4.2	Positive (25.9)	Positive (27.1)
13	ICU	Proveng	Solid cancer	Necrotizing lesions	Positive	Positive (A. fumigatus)	2.0	4.4	Positive (22.1)	Positive (24.3)
14	HEM	Probable	NHL	Halo	Negative	Negative	1.9	3.5	Positive (27.1)	Positive (28.1)
15	HEM	Probable	AML	Halo	Negative	Negative	0.9	2.6	Positive (29.0)	Positive (31.1)
16	HEM	Probable	AML	Nodules	Negative	Positive (A. fumigatus)	0.8	4.2	Positive (26.3)	Positive (28.1)
17	HEM	Probable	NHL	Nodules	Negative	Negative	0.8	1.1	Negative (37.2)	Negative

^aIA was diagnosed according to the revised European Organization for Research and Treatment of Cancer/Mycoses Study Group criteria from 2002 (10).

^bAML, acute myeloblastic leukemia; ALL, acute lymphoblastic leukemia; COPD, chronic obstructive pulmonary disease; NHL, non-Hodgkin's lymphoma.

^cAn optical density (OD) index of ≥1.0 was used as a cutoff value for positive BAL GM (7, 27).

^dA threshold of 36 cycles corresponding to a target sensitivity of ≤50 18S rRNA copies was used as a cutoff value for positive BAL PCR (9).

^eNA, not available.

^fAs defined by positive histopathology of lung biopsy.

^gAs defined by positive culture of pleural fluid drain.