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Diagram of domains in gp41 and amino acid sequences of corresponding peptides. HR1 and HR2 correspond to the first and second heptad repeat motifs in gp41, respectively. FP, fusion peptide; TM transmembrane domain; C-tail, cytoplasmic tail. Numbers denote amino acids starting at gp160 according to the nomenclature of the HXB2 reference clone. The sequence of gp41 corresponds to the JR-CSF molecular clone used for these studies a and d indicate positions in the heptad repeats.
