Fig. 3.

SPR analyses of sCD4 interactions with human anti-gp120 MAbs. Threefold serial concentrations of sCD4 were flowed over human anti-gp120 MAbs that were immobilized on a protein A-coated CM4 chip. MAb 19e (filled circles), MAb 21c (open circles), and MAb C11 (filled triangles) were tested in duplicate experiments. Average values are shown; error bars indicate highest and lowest values. The inset shows sensorgrams for each MAb tested at 130 μM: MAb 19e, black line; MAb 21c, red line; MAb C11, blue line.