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. 2011 Dec;85(24):13453–13456. doi: 10.1128/JVI.06064-11

Fig. 2.

Fig. 2.

Morphological analysis of the HBV transgenic mouse liver. (A) Hematoxylin and eosin staining of the liver tissue sections of HBV mice without (left) and with (right) the Atg5 knockout. (B) Comparison of the livers of naïve, wild-type mice (left panel) and HBV mice without (middle panel) and with (right panel) the Atg5 knockout. (C) Comparison of the average liver weights of HBV transgenic mice with and without the Atg5 knockout. The numbers under the bars indicate the numbers of mice analyzed. The average mouse liver weights without and with the Atg5 knockout were 1.03 ± 0.07 g and 2.62 ± 0.29 g, respectively. HBV by itself did not significantly alter the morphology of hepatocytes or liver size. However, the Atg5 knockout significantly enlarged hepatocytes and the liver. Two-month-old male mice were used in this study and our subsequent studies unless otherwise indicated.