Fig. 4.

Comparison of the ability of T cells from the cervical and blood samples from HIV-infected (n = 15) and uninfected women (n = 39) to produce IFN-γ and IL-2 after global stimulation with PMA-ionomycin. The net frequencies of CD8 and CD4 T cells from the cervix and blood samples from HIV-positive (HIV+) versus HIV-negative (HIV−) women were compared. The data are shown as box-and-whisker plots, with the bottom of the box the 10th percentile, the top of the box the 90th percentile, and the median the middle of the box and the whiskers showing the minimum and maximum values. The responses were compared for each group using the Mann-Whitney U test, and P values of ≤0.05 were considered significant (**, P < 0.005; ***, P < 0.001).