Table III.
Longitudinal comparisons of prebronchodilator pulmonary function (spirometry) between groups of children from ages 5 through 8 y∗ with early childhood RV wheezing illnesses and children without
| RV wheeze 1st 3 y |
RSV wheeze 1st 3 y |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No | Yes | Diff | 95% Cl | P value | No | Yes | Diff | 95% Cl | P value | |
| n | 152 | 73 | 160 | 65 | ||||||
| FVC | 1.61 (0.02) | 1.54 (0.03) | −0.07 | (−0.13, 0.00) | .04 | 1.57 (0.02) | 1.58 (0.03) | 0.01 | (−0.04, 0.07) | .66 |
| FVC PP | 105 (1) | 102 (2) | −3 | (−8, 1) | .13 | 104 (1) | 103 (2) | 0 | (−4, 4) | .90 |
| FEV1 | 1.38 (0.02) | 1.28 (0.02) | −0.10 | (−0.16, −0.04) | .001 | 1.33 (0.02) | 1.33 (0.02) | 0.00 | (−0.05, 0.05) | .97 |
| FEV1 PP | 103 (2) | 97 (2) | −6 | (−11, −1) | .01 | 101 (1) | 100 (2) | −1 | (−5, 3) | .72 |
| FEV0.5 | 1.06 (0.02) | 0.96 (0.02) | −0.10 | (−0.16, −0.04) | .0005 | 0.01 (0.02) | 1.01 (0.02) | −0.01 | (−0.05, 0.04) | .83 |
| FEF25-75 | 1.46 (0.05) | 1.21 (0.05) | −0.25 | (−0.37, −0.12) | .0002 | 1.34 (0.04) | 1.32 (0.05) | −0.02 | (−0.13, 0.09) | .70 |
| PEFR | 2.79 (0.06) | 2.59 (0.07) | −0.21 | (−0.38, −0.04) | .02 | 2.72 (0.06) | 2.66 (0.07) | −0.06 | (−0.21, 0.08) | .40 |
| FEV1/FVC | 0.87 (0.01) | 0.84 (0.01) | −0.02 | (−0.04, 0.00) | .01 | 0.85 (0.01) | 0.85 (0.01) | −0.01 | (−0.02, 0.01) | .55 |
| FEV0.5/FVC | 0.67 (0.01) | 0.63 (0.01) | −0.03 | (−0.06, −0.01) | .008 | 0.65 (0.01) | 0.65 (0.01) | −0.01 | (−0.03, 0.01) | .48 |
FEF25-75, Forced expiratory flow at 25% to 75% of FVC; FEV1 PP, FEV1 percent predicted; FVC, forced vital capacity; FVC PP, FVC percent predicted; PEFR, peak expiratory flow rate.
Longitudinal analyses for lung function obtained from children aged 5 through 8 y adjusted for age, race, gender, height, weight, asthma, RV wheeze, RSV wheeze, non-RV/non-RSV wheeze, passive smoke exposure, and age at the first occurrence of positive aeroallergen FEIA. Percent-predicted values adjusted for asthma, RV wheeze, RSV wheeze, non-RV/non-RSV wheeze, smoke, and FEIA only. Groups summarized by least-squares means (standard error).