Table.

A list of mutant mice with whisker map deficits

protein	gene name / global or cortex-specific KO	barreletts in BSTC	barreloids in thalamus	whisker-related TCA clusters in the S1 cortex	barrels in the S1 cortex	synaptic function/ plasticity	references
adenylyl cyclase 1	Adcy1 / global KO	Normal	Small barreloids not well delineated	No whisker related pattern; single TCA analysis found normal number of axonal length, branch and bouton numbers while axonal spans are larger	No whisker related pattern	Defective glutamatergic release, AMPAR trafficking, and long-term plasticity in thalamocortical synapses. In vivo single unit recording revealed normal topography for whisker map despite a decrease in the response latency for surrounding whiskers	(Welker et al., 1996; Abdel-Majid et al., 1998; Lu et al., 2003; Gheorghita et al., 2006; Lu et al., 2006)
adenylyl cyclase 1	Adcy1 / cortex- specific KO by EMX-Cre	Normal	Normal	Normal	Barrels are evident but layer IV spiny stellate neurons have reduced dendritic asymmetry and increased dendritic span	AMPA/NMDA current ratio is reduced at P11; reduced amplitude of evoked AMPA mediated currents	(Iwasato et al., 2008)
cAMP-dependent protein kinase type II regulatory subunit	Pka-R2 / global KO	Normal	Normal	Normal	No whisker related pattern	Impaired thalamocortical LTP formation and AMPAR trafficking	(Inan et al., 2006; Watson et al., 2006)
NMDA receptor subunit 1	Grin1 / global KO	No whisker related pattern	No whisker related pattern	No whisker related pattern	No whisker related pattern	Evoked NMDAR-responses are reduced in layer IV neurons of S1	(Li et al., 1994; Iwasato et al., 1997; Rudhard et al., 2003)
NMDA receptor subunit 1	Grin1 / cortex- specific KO by EMX-Cre	Normal	Normal	TCAs form rudimentary pattern for caudo-dorsal whiskers; analysis of single TCA shows reduced branching and reduced total axon arbor length but wider distributions	No whisker related pattern; layer IV spiny stellate neurons have symmetric dendritic morphology and their dendritic spans, total dendritic lengths, and spine numbers are increased	N. A.	(Datwani et al., 2002; Lee et al., 2005; Iwasato et al., 2000)
NMDA receptor subunit 2B	Grin2b / genetic mosaic*	N. A.	N. A.	N. A.	KO neurons have symmetric dendritic morphology	N. A.	(Espinosa et al., 2009)
metabotropic glutamate receptor 5	Grm5 or Mglur5 / global KO	Small barreletts not well delineated	Small barreloids not well delineated	TCAs form rudimentary pattern for caudo-dorsal whiskers; analysis of single TCA shows reduced complexity and reduced total axon arbor length while the axonal span is increased	No whisker related pattern; layer IV spiny stellate neurons have symmetric dendritic morphology and increased dendritic span.	Abnormal thalamocortical LTP /LTD formation; faster NMDA current decay kinetics; normal presynaptic function; mEPSC’s frequency is increased while mIPSC’s frequency is reduced	(Hannan et al., 2001; Wijetunge et al., 2008; She et al., 2009), (Ballester-Rosado et al., 2010)
metabotropic glutamate receptor 5	Grm5 or Mglur5 /cortex-specific KO with NEX- Cre	Normal	Normal	TCAs form rudimentary pattern for caudo-dorsal whiskers; analysis of single TCA shows reduced complexity and reduced total axon arbor length while the axonal span is increased	No whisker related pattern; layer IV spiny stellate neurons have symmetric dendritic morphology and increased dendritic span and segment numbers	mIPSC’s frequency is reduced while mEPSC’s frequency is normal	(Ballester-Rosado et al., 2010)
Phospholipase C, beta1	Plcb1 / global KO	N. A.	N. A.	Normal	No whisker related pattern	N. A.	(Hannan et al., 2001)
synaptic Ras GTPase activating protein 1	Syngap1 / global KO	Normal	Small barreloids are not well delineated	Rudimentary pattern for caudo-dorsal whiskers	KO: No whisker related pattern; het: reduced barrel segregation	N. A.	(Barnett et al., 2006)
monoamine oxidase type A	MAOA / global KO	Normal	Small barreloids are not well delineated	No whisker related pattern or rudimentary pattern for caudo- dorsal whiskers	No whisker related pattern	N. A.	(Cases et al., 1996)
sodium- dependent serotonin transporter	SERT; 5-HTT / global KO	KO: barreletts are poorly defined; HET: small barreletts that are not well delineated	KO: barreloids are poorly defined, VPM is smaller; het: barreloids are not well delineated	KO: no whisker related pattern except a rudimentary pattern for a few large caudal whiskers; het: blurry boundaries for TCA clusters	KO: no whisker related pattern; het: septa between barrels are larger	N. A.	(Persico et al., 2001)
monoamine oxidase A; serotonin transporter	MAOA; 5-HTT DKO	N. A.	Small medioventral barreloids are poorly delineated	No whisker related pattern	No whisker related pattern	N. A.	(Salichon et al., 2001)
monoamine oxidase A; serotonin receptor 1B	MAOA;5-HT1B DKO	N. A.	Normal	Normal	Fuzzy whisker-related pattern with reduced barrel segregation.	N. A.	(Salichon et al., 2001)
MAOA; 5-HTT; 5- HT1B TKO	MAOA; 5-HTT; 5-HT1B TKO	N. A.	N. A.	Normal	Fuzzy whisker-related pattern with reduced barrel segregation.	N. A.	(Salichon et al., 2001)
LIM domain transcription factor LMO4	Lmo4 / cortex-specific KO with NEX- Cre	N. A.	N. A.	TCAs form rudimentary pattern for caudo-dorsal whiskers	No whisker related pattern	N. A.	(Kashani et al., 2006)
neurogenic differentiation factor 2	Neurod2 / global KO	Normal	Normal	Rudimentary pattern for caudo-dorsal whiskers	No whisker related pattern	Reduced AMPA/NMDA current ratios and reduced spontaneous EPSC amplitude	(Ince-Dunn et al., 2006)
brain derived neurotrophic factor	BDNF / global KO	N. A.	N. A.	Delayed appearance of whisker pattern	N. A.	Reduced AMPA/NMDA current ratios; defective LTP formation, and increased the number of silent synapses in TC synapses; altered development of fast-spiking GABAergic neurons	(Itami et al., 2003; Lush et al., 2005; Itami et al., 2007)
tropomyosin receptor kinase B receptor	NTRK2; TrkB/ global KO	N. A.	N. A.	Delayed appearance of whisker pattern	N. A.	N. A.	(Lush et al., 2005)
tropomyosin receptor kinase B receptor	NTRK2; TrkB / cortex-specific KO with hGFAP-Cre	N. A.	N. A.	Normal	N. A.	N. A.	(Lush et al., 2005)
EphrinA5	EFNAS / global KO	N. A.	N. A.	Normal whisker-related pattern but the number and length of TCA arbors are reduced	N. A.	N. A.	(Uziel et al., 2008)
neurofibromin	Nf1 / cortex- specific with hGFAP-Cre	N. A.	N. A.	Smaller TCA clusters and bigger septa area	No whisker related pattern	N. A.	(Lush et al., 2008)

Protein names and gene names based on www.uniprot.org