Skip to main content
. Author manuscript; available in PMC: 2011 Dec 7.
Published in final edited form as: Psychopharmacology (Berl). 2009 May 9;205(3):467–474. doi: 10.1007/s00213-009-1555-y

Fig. 5.

Fig. 5

Effects of cocaine (0.1–1.0 mg/kg; a) and diphenhydramine (DPH; 1.7–3.0 mg/kg; b) alone or in combination on extracellular dopamine levels in the caudate nucleus of rhesus monkeys (n=3–5). Data in a and b are expressed as percent baseline dopamine levels and plotted as mean±SEM. Average (±SEM) dopamine levels were estimated at 6.84±0.5 ng/mL. Data in c are represented as peak dopamine effect for each treatment condition. The three cocaine and DPH dose combinations tested were (from left to right): 0.1 mg/kg cocaine and 1.7 mg/kg DPH, 0.3 mg/kg cocaine and 1.7 mg/kg DPH, and 0.3 mg/kg cocaine and 3.0 mg/kg DPH. Asterisk indicates significantly different from percent baseline levels averaged during the first 60 min of the experiment before drug challenge