Table 3.
BACTERIAL & VIRAL PLDs
| SPECIES | ENZYME | ACTIVITY | FUNCTION | LOCALIZATION |
|---|---|---|---|---|
| Orthopox virus | p37 | PLC, PLA, PLA2 | IMV wrapping | TGN & inner membrane wrapping of EEV |
| (Vaccinia, variola) | TAG lipase | IEV fusion & release | ||
| transphosphatidylation | ||||
| Orthopox virus | K4 | endonuclease | single strand (ss)/double strand (ds) DNA torsion release | within IMV |
| (Vaccinia, variola) | Nick-joining enzyme | |||
| Salmonella typhimurium, Escherichia coli | Nuc | nonspecific endonuclease | ssRNA | periplasm |
| breakage during DNA conjugation | ||||
| Escherichia coli | Bfil | site-specific endonuclease | Degrades dsDNA during DNA conjugation | periplasm |
| Neisseria gonorrhoeae | NgPLD | PC hydrolysis | combination of lipase & protein-protein interaction elicits bacterial invasion | host cell cytoplasm |
| transphosphatidylation | binds AKT to trigger membrane ruffling | extracellular milieu | ||
| Yersinia pestis | YMT | PLD (PC/PE lipase) | in vivo facilitates Y. pestis colonization of flea gut | bacterial cytosol |
| (formerly Pasteurella pestis) | transphosphatidylation | protects against murine plasma component | ||
| Chlamydiae | chromosomal pz PLDs | PLD | unknown | reticulate bodies |
| unknown lipase activity | lipid acquisition from LD | |||
| transphosphatidylation | ||||
| Acinetobacter baumanii | Act bau PLD | unknown | unknown function | secreted |
| enhances serum survival/host cell invasion | ||||
| Pseudomonas aeruginosa | PLDa gene | PLD (PC → PA) | increases long term infectivity/bacterial homeostasis | periplasm |
| transphosphatidylation | ||||
| Streptomyces sp | PMF PLD | PLD | unknown | periplasm |
| transphosphatidylation | secreted |