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Mammalian PLD regulatory proteins
| CLASS | ACTIVATOR | PLD ISOFORM | CONSEQUENCE |
|---|---|---|---|
| small GTPase | Arf | PLD1, PLD2 | activate (kcat) |
| RhoA | PLD1 | activate (Km) | |
| Rac1 | PLD1 | activate (Km) | |
| Rac2 | PLD2 | activate | |
| Cdc42 | PLD1 | activate (Km) | |
| Kinase | PKC | PLD1 (PLD2) | activate (kcat & Km) |
| Src | PLD2 | phosphorylate | |
| Other | Gβγ | inhibit | |
| Grb2 | PLD2 | activate | |
| F-actin | activate | ||
| G-actin | inhibit | ||
| Amphyphysin II | inhibit | ||
| AP3/AP180 | inhibit |
