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Metabolism of S-1.
Abbreviations: 5-FU, 5-fluorouracil; CDHP, gimeracil; CYP2A6, cytochrome P450 2A6; DPD, dihydropyrimidine dehydrogenase; FUH2, 5-fluorodihydrouracil; FUMP, fluorouridine monophosphate; OPRT, orotate phosphoribosyltransferase; Oxo, oteracil potassium.
